Label first
Ingredients and research, in context
Five listed ingredients, the exact amounts on the label, and the published research on each, with the gaps stated plainly.
How to read the research below
- Ingredient study, not product study
- Each source tests one ingredient. None tested a BRYO pouch.
- Dose
- Label amounts per pouch are often far below study regimens. Do not use extra pouches to match them.
- Population
- Many trials enrolled specific groups, such as older adults, not healthy general users.
- Delivery
- Capsules, drinks or powders absorb differently from an oral pouch.
Read the product label
The Supplement Facts are shown below. Open the image to zoom in. The text below reproduces the listed ingredients and amounts; blank daily values have not been filled in.
Supplement Facts
Serving size: 1 (one pouch). Servings per container: 15.
| Ingredient | Amount |
|---|---|
| Alpha-GPC | 50 mg |
| L-Theanine | 50 mg |
| Vitamin B6 | 2 mg |
| Vitamin B12 | 100 mcg |
| Lions Mane Mushroom | 50 mg |
The label’s % Daily Value column is blank.
Other ingredients: Microcrystalline Cellulose (MCC), MCT Oil, Natural and Artificial Flavoring, Mannitol, Vegetable Glycerine (VG), Sucralose, Water, Propylene Glycol (PG), Sodium Bicarbonate, Sodium Citrate, Sodium Chloride, Silicon Dioxide.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Use warnings: Keep out of reach of children. Not intended for persons under 18 years of age. Do not use if pregnant or nursing. Consult your physician before use if you have a medical condition or are taking medication.
Evidence & Limitations
Ingredient research, in context
Alpha-GPC
This review included seven randomized trials and one cohort study in adults aged 50+ with neurological conditions and cognitive impairment, not healthy consumers. Three studies over 90–180 days reported a pooled 3.5-point MMSE difference versus placebo or acetyl-L-carnitine, with very high heterogeneity (I² = 98%). Other trials combined Alpha-GPC with medication. These findings do not establish efficacy or safety for BRYO.
Journal of Alzheimer's Disease, 2023
L-Theanine
The review covered 31 trials (1,168 participants) across healthy and clinical populations. Its attention analysis found improved choice reaction time in healthy adults after 200 mg taken 30–60 minutes before testing; not all 31 trials tested that outcome. No significant fatigue benefit was found, and stress results were influenced by high-risk-of-bias studies. This is not evidence of BRYO's effect or onset time.
Molecular Psychiatry (Nature), 2026
Lion's Mane
Thirty Japanese adults aged 50–80 with mild cognitive impairment took placebo or four 250 mg tablets three times daily for 16 weeks. Tablets contained 96% mushroom dry powder (2.88 g/day). Cognitive-scale scores were higher versus placebo at weeks 8, 12, and 16, then declined four weeks after stopping. This small study does not establish effects in healthy adults or from BRYO's different dose and pouch format.
Phytotherapy Research, 2009
Vitamin B6
The NIH fact sheet describes B6's role in more than 100 enzyme reactions, mostly protein metabolism, and in neurotransmitter synthesis. This is a nutrient reference, not a BRYO trial or a tested product dose. It reports insufficient evidence that B6 supplementation improves cognition. Normal vitamin function does not establish extra energy or focus from supplementation in people with adequate intake.
NIH Office of Dietary Supplements
These sources study individual ingredients, not BRYO. Populations, doses, preparations, and delivery methods differ from our pouch. They do not prove that BRYO improves focus, energy, or performance. Do not use extra pouches to try to match research doses.
Studies shown reflect research on the individual ingredients, not on BRYO itself. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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Every flavor uses the label above.